Research Is at the Heart of Everything We Do

We are committed to providing clinical solutions, backed by research and evidence-based data.

Inspired by Love. Rooted in Research.

Using double-blind, peer-reviewed veterinary clinical studies, we’ve firmly rooted our products in the scientific veterinary community by verifying that our proprietary targeted pulsed electromagnetic field (tPEMF™) technology significantly reduces pain and inflammation in animals.

Now we’ve taken the research one step further with the development of a new tPEMF signal created to reduce anxiety in dogs. We explored the potential for this new signal in our 2019 pilot study, which examined the efficacy of the new Calmer Canine® device in treating dogs with separation anxiety.

Peer-Reviewed Veterinary Clinical Trials: Proving the Effect of the Assisi Loop®

Trial published in the Journal of the American Animal Hospital Association, 20191

This double-blind, randomized, placebo-controlled clinical trial found that using the Assisi Loop to treat dogs suffering from intervertebral disk disease (IVDD) resulted in:

  • Significant improvement in wound healing for Loop treated group compared to placebo
  • Reduction in opioid administration: opioids were administered almost 50% less frequently in Loop treated group
  • No side effects

Trial published in the Journal of Neurotrauma, 20182

This randomized, placebo-controlled, prospective clinical trial found that using the Assisi Loop to treat dogs with spinal cord injuries (SCI) due to acute intervertebral disc extrusions (IVDE) resulted in:

  • Significant difference in incisional pain between Loop treated and placebo group
  • Lower levels of GFAP indicating neuroprotective qualities
  • Statistically greater degree of recovery of proprioception

1 Leilani X. Alvarez, John McCue, Nathaniel K. Lam, Gulce Askin, and Philip R. Fox (2019) Effect of Targeted Pulsed Electromagnetic Field Therapy on Canine Postoperative Hemilaminectomy: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Journal of the American Animal Hospital Association: March/April 2019, Vol. 55, No.

2Zidan N, Fenn J, Griffith E, Early PJ, Mariani CL, Muñana KR, Guevar J, Olby NJ. J Neurotrauma. 2018 Aug 1;35(15):1726-1736. doi: 10.1089/neu.2017.5485. Epub 2018 Apr 2.

Proving the Effect of the Calmer Canine Anxiety Treatment System™

Pilot Study Presented July 2019 at the IVBM Conference, Washington DC.3

This pilot study testing the efficacy of the Calmer Canine device on dogs with separation anxiety found that:

  • 100% of cases saw improvement in overall severity score after a month of treatment.
  • Half of owners reported complete resolution of CSA symptoms after six weeks of therapy
  • Signs of CSA continued to improve or remained at their reduced level in two-thirds of the dogs, even after treatment had been discontinued for two weeks

Watch before and after video footage from the pilot study.

Double-Blind, Randomized, Placebo-Controlled Study Published December 20, 2021 in Front. Vet. Sci. 8:775092.4

This double-blind, randomized, placebo-controlled study found that using Calmer Canine on dogs with separation anxiety resulted in:

  • Half of owners documenting improvement in their dog’s anxiety after one week of treatments
  • Almost two-thirds of dogs saw 100% or greater reduction in anxious symptoms after four weeks of treatments

Anxiety Citations

3 Margaret E. Gruen, Emily Griffith, Judy Korman. Treatment of Canine Separation Anxiety Using a Pulsed Electromagnetic Field Device: A Pilot Study. Presented July 2019 at the IVBM Conference, Washington DC.

4 Pankratz K, Korman J, Emke C, Johnson B, Griffith EH, Gruen ME. Randomized, Placebo-Controlled Prospective Clinical Trial Evaluating the Efficacy of the Assisi Anti-anxiety Device (Calmer Canine) for the Treatment of Canine Separation Anxiety. Front Vet Sci. 2021 Dec 20;8:775092. doi: 10.3389/fvets.2021.775092. PMID: 34988140; PMCID: PMC8720769.

Human Clinical Studies: The History of tPEMF

In 2010 the FDA cleared PEMF technology for use on humans. In the past decade, research into its efficacy has been mounting in both human and animal science. Since 2013, Assisi’s clinical studies have been based on tPEMF technology and its effectiveness in pain management, advancing healing, and control of anxiety. Some of the most significant human studies are listed below, along with their conclusions with regard to the benefits of tPEMF therapy:

  • Accelerated wound closure(Kloth, et al., Electricity and Magnetism in Biology and Medicine, 1999)5
  • Angiogenic (blood vessel forming) effect (Weber, et al., Plastic and Reconstructive Surgery, 2004)6
  • Increased tensile (maximum) strength (Strauch, et al., J Hand Surg, 2006)7
  • Reduced pain and edema(Pilla, A., Bioelectromagnetic Society Meeting, 2008)8
  • Accelerated surgical recovery (Rohde, C., et al., Plastic and Reconstructive Surgery, 2010)9
  • Reduced arthritic pain (Nelson, Pilla, et al., Rheumatology Int, 2012)10
  • Substantial improvement observed in mood following low field magnetic stimulation treatment (Rohan, et al., Biological Psychiatry, 2013)11
  • Accelerated surgical recovery and reduced inflammation (Rhode, C., et al., Plastic and Reconstructive Surgery, 2015)12

Citations for Human Research with Links